… and degeneration, and how ageing is a major influencer of both these features. … In IBM,
proteasome components are increased in cultured muscle fibres of IBM patients; yet, proteasomal …

… co-culture system to myotubes derived from primary satellite … are presented as fold increases
as compared with basal (No-… , with all being categorized as elderly, background features, ie…

… opposite directions of expression change (eg, increased in biopsy vs decreased in myotube).
… A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities…

… found its enzymatic activity was increased in IBM muscle (55), … Myogranules from cultured
myocytes did not express markers of … disease associated with aging and abnormalities of …

… pro-inflammatory cell culture model using human myoblasts and primary human myotubes.
… We found a significant increase of the mRNA level for NLRP3 in stimulated cells compared …

… Because our results raise the possibility of the … that the GDF15 level in myoblast culture
medium was increased by BSO and … found in cardiac and skeletal muscles during aging [52]. The …

… size of p62 puncta, but this may represent increased autophagic flux instead of … cultures
with sIBM-like inflammatory mediators may be warranted to investigate muscle weakness. …

… Aging is known to diminish the regenerative capacity of … that muscle from subjects with IBM
exhibits increased numbers of … with in vitro studies showing primary myotubes cultured with …

… We focused on inclusion body myositis, as a major … exercise in inclusion body myositis that
showed to increase strength … indicated an accelerated mitochondrial muscle aging in IBM, …

… in IBM muscle and controls, suggesting an accelerated aging … the primary driver of the
disease [37]. The development of IBM-specific pathology in myotube cultures and mouse muscles …